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Digestion and motility of luminal content through the gastrointestinal (GI) tract are achieved by cooperation between distinct cell types.
While analyzing the performance of the proposed profiling method, we focused on measurements of differential expression between distinct cell types instead of absolute measurements of one cell type.
Our results provide additional evidence for the relationship between brown preadipocytes and muscle, and show that this assay technology can be used to examine similarities between distinct cell types, and to dissect subtle differences between cell types thought to be similar.
The balanced inter-conversion between distinct cell types may be biologically important and relevant for maintaining the heterogeneity of cancers.
Taken together, RED-seq not only detects large differences in chromatin accessibility between distinct cell types (ESCs vs MEFs) but also tracks more subtle changes that occur during differentiation (control vs Oct4 KD ESCs).
Gene expression analyses have proved useful for dissecting the basis of the changes that occur as cells and organisms transition between distinct cell types [ 1- 3], developmental stages [ 4- 6] or progress into disease states [ 7, 8].
Similar(52)
These orchestrate complex shape changes and movements that entail interactions between five distinct cell types.
C4 plants partition photosynthetic reactions between two distinct cell types: vascular bundle sheath (BS) and mesophyll (M) cells, a structure called 'Kranz' anatomy (Majeran and van Wijk 2009).
Nevertheless, accumulating evidence suggests that boundaries between physiologically distinct cell types might be less clear than usually believed.
To do so seems only to confuse the differences between functionally distinct cell types.
The physiological activities of organs are underpinned by an interplay between the distinct cell types they contain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com