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Variation in the intensity of myocardial inflammation between different virus strains has previously been reported for Cocksackie B virus, a related virus within Picornaviridae [[ 14]].
The method therefore has the potential to be used in examining the cross-reactivity of antibodies/sera between different virus strains, an essential part of influenza vaccine choice, development and testing.
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Between the different virus strains, viral RNA titers were the highest in the organs of birds infected with strain Greece-10 or 578/10, followed by NY99 and Ita09; titers were significantly higher than those for birds infected with strain FIN (p = 0.005 for all).
The reason for this strikingly different behavior of HEF proteins is unknown, but either subtle amino acid differences between HEF proteins of different virus strains or between the cloned HEF-gene and the gene present in virus particles of C/JHB/1/66 have been discussed (Pekosz and Lamb, 1999).
Because different virus strains are evolutionarily related, a relationship between 5' and GC content may be confounded by the viral phylogeny [ 16].
Indeed, when combination therapy was simulated using the two models against different virus strains, the −IM model consistently reported a lower synergy between AMT and OP compared to the +IM model.
The CGE method allowed identification of different virus strains based on their specific protein profile.
The mixed infection of different virus strains also occurs [ 3, 6, 7], and dominant virus strains are variable [ 8].
The virus strain differentiation is complex, with both of the virus members that cause sugarcane mosaic disease having several different virus strains [ 5].
Thus, it is not surprising that MDCK cells infected with different virus strains and under different conditions do show a different metabolic response to virus infection.
Whenever possible, corresponding viral protein of different virus strains were included as samples and annotated.
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