Exact(3)
Over and above these proposed mechanisms, however, it is likely that cancer-associated changes in the regulation of PLK1 levels additionally contribute to the differences in levels between different tumour samples (see below).
Isolation efficiency of TStrC did not vary considerably between different tumour samples.
The advantage of the newer microarray technologies is the ability to measure the RNA expression of thousands of genes at one time, and to relate how the gene expression pattern of one gene correlates to the expression of other genes in or between different tumour samples, or to measure DNA amplification or loss of DNA.
Similar(57)
Moreover, no staining intensity differences were observed among the different tumour samples.
The Spearman's rank correlation was calculated between these two data sets for three different tumour samples (Additional file 1: Figure S2) and the Spearman's rho ranged from 0.63 to 0.81 (p value <0.001).
(A) The lineage of the different tumour samples characterised.
Following the Endostatin immunostaining of the microarrays, 255 different tumour samples were available for analysis.
For one of these patients, two different tumour samples were available.
In cancer, miRNA expression profiles differ between normal tissues and tumour samples and between different tumour types (Lu et al, 2005), and CpG island hypermethylation accounts for the transcriptional silencing of a subset of miRNAs (Saito et al, 2006; Lujambio et al, 2007).
We found no appreciable difference in SPRED1 transcript comparing benign with tumour samples or indeed between different tumour grades.
We also found some intra-tumoral variability in distribution of PROX1-positive cells, as well as a minor variation in staining intensity between different tumour cells within the same sample.
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