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It has been known that the severity of the disease varies between different study populations as well as between different geographical regions.
Even among patients with similar severity of their condition, very different psychological and behavioral characteristics were found between different study populations.
Some neurologists would prefer natalizumab for JCV-negative patients due to the numerically higher reduction of ARR in pivotal trials, although treatment effect cannot be directly compared between different study populations.
Thus, it is conceivable that chemosensitisation reported with EGFR inhibition may be related to the cytotoxic used alongside gefitinib, although it is difficult to compare between different study populations.
In line with the observations in microarray gene expression studies, it has been shown that in those cases where there is only a modest overlap in the variant or gene-level findings between different studies, due to factors such as differences in the genetic structure, the pathway-level associations may be much more reproducible even between different study populations [ 57- 60].
Finally, given that association studies rely on the existing linkage disequilibrium (LD) between the genotyped markers and the actual functional disease susceptibility variant (typically not genotyped), heterogeneity in the extent of this LD between different study populations could also account for inconsistent results between different studies.
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The mean number of journeys undertaken outside the study area within the 7 days prior to the questionnaire being taken varied markedly between the different study populations, see Table 2, with those in urban Huangshan travelling much more frequently than any other group.
Comparisons between the different study populations and time points were performed using one-way repeated-measures analysis of variance, including an all-pair wise comparison.
However, the intervals between data collection, blood sampling, and diagnosis differ substantially between the three different study populations, something that might be considered a limitation of the study.
High variability between studies reflects different study populations and study methods as well as different follow-up periods (1 40 years).
The WHO MONICA study was conducted in 38 populations in 21 countries and reports annual percentage decreases in coronary event rates of 2.3% in men and 1.4% in women (5), but these rates differ significantly between and within the different study populations (3).
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between different cell populations
between different study cohorts
between different study strategies
between individual study populations
between different mapping populations
between different study designs
between different study architectures
between different study parameters
between different study arms
between different study outcomes
between different study sites
between local study populations
between different natural populations
between different study types
between different cancer populations
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