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Different types or rates of antibiotic resistance might account for some degree of discrepancy between different study outcomes.
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No significant difference was found in outcome between different study centers (data not shown).
To allow comparison between different studies and their outcomes, it is essential that animal models, fixation devices, surgical procedures and methods of taking measurements are well standardized to produce reliable data pools and act as a base for further directions to orthopaedic and tissue engineering developments, specifically translation into the clinic.
A major disadvantage of this approach is that assumptions have to be made about factors such as the circulating drug concentration being proportional to that at the site of pathogen load, or the transferability of outcomes between different studies.
There is a range in the outcomes reported between different studies as a variety of different techniques have been used and studies have reported baseline levels and responses to stimulation.
This makes comparison between different studies difficult and a consensus approach to reporting clinical outcomes should be considered.
Fan and colleagues [ 43] compared the predictions derived from five gene expression profiling studies, and the resulting analysis suggested that even though there was little gene overlap between the different studies, the outcome predictions were similar and probably tracked the same phenotype, illustrated by the same functional clusters.
The ability of the models to discriminate between different outcomes was studied by estimating the area under the receiver operating characteristics curve (AUC).
Associations between different alcohol outcomes and outlet density measures vary between studies and may not be generalisable to adolescents.
Therefore, the unknown proportions of patients with cervical involvement complicate interpretation of outcomes and impair comparison between the different studies.
In addition, our analysis did not discriminate between the impact of the different modes of public commitment on study outcomes.
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