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This point is critical given the observation made by Meshorer et al. from live cell imaging, that stem cell chromatin actively 'breathes' between different structural conformations associated with hyperdynamic binding of structural proteins [ 2, 4, 5].
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Recent EM study also reveals that TRPV4 forms a "hanging gondola -like structure which undergondola -liket structurel conformations representing open and closed state of the channel [69].
All entities are located in subcellular compartments and macromolecular ones can also be cleaved, modified, or adopt different structural conformations.
How distinct signaling responses are triggered by the different structural conformations resulting from cis vs trans interactions remains poorly understood.
Furthermore, many enzymes may exhibit widely different structural conformations, distinguishable by protease sensitivity, antibody recognition, circular dichroism or fluorescence (7).
However, we have previously shown that different structural conformations of mtDNA (supercoiled, nicked circular, linear) have different effects on real-time PCR quantification [ 34].
The O-glycan cores are usually lengthened and modified by addition of diverse sugars and sulphate esters, thus generating different structural conformations.
Perhaps, the F-actin bound form of ACTN4 adopts a different structural conformation than ACTN4 alone.
This stabilization in a different structural conformation may be the key to the competitive inhibition of Eg5 activity.
We speculate that linezolid-dependent cells may possess linezolid-dependent ribosomal precursor particles exhibiting different structural conformation, which favors a faster rate of the overall protein synthesis recovery.
However, the fact that there is less YR enrichment in mouse TSSs might mean that the initiation assembly in this species may require different DNA structural conformations.
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