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Despite this, no study to date directly addressed the relationship between different sampling intervals and V̇O2max attainment during the verification phase.
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In contrast, sampling frequency had only a minor effect on the fit parameters in the case of the 300-s infusion simulations, despite some significant differences between the fits with different sampling intervals.
A sampling interval was calculated for each ward; wards had different sampling intervals due to differing population structures.
The nugget represents the minimum semivariance among different sampling intervals.
For simplicity, we assume identical sampling intervals in both coordinates, but using different sampling intervals for each coordinate is straightforward (Different sampling intervals influence the accuracy of the field approximation only but not the principal features of the decentralized estimator).
For selecting the study participants' different sampling intervals were used for each sub-district.
The sampling scheme that relies on constant time intervals ∆t between different samples yielded the lowest errors.
The D. melanogaster data have lower temporal resolution, but show similar trends, both for values averaged between different samples representing the same developmental interval (fig. 2 a, right), and for individual samples (supplementary fig. S1, Supplementary Material online).
When two blood samples were used, median and interquartile ranges of RMS norm and AUC errors were tabulated for the six possible combinations of early, intermediate and late blood-sampling intervals, and ANOVA was used to assess differences in these metrics between different combinations of sampling intervals.
The performance of dynamic controller is also analyzed for different inputs and sampling intervals.
Each sampling interval lasted 3 4 days and gaps between sampling intervals lasted 5 10 days.
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