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Indeed, studies of rats have shown that exposure to chronic unpredictable stress increases the levels of a dopamine-metabolizing enzyme, tyrosine hydroxylase (TH), in the VTA but that the extent of this increase differs drastically between different rat strains (Ortiz et al. 1996).
To identify genomic regions shared between different rat strains, relative SNV density (RSD) in nonoverlapping 10kb windows was calculated.
Identification of Putative Artificial Selective Sweep Regions To identify genomic regions shared between different rat strains, relative SNV density (RSD) in nonoverlapping 10kb windows was calculated.
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Due to ethical constraints, we calculated the sample size required to detect a difference in baseline ICP between two different rat strains (Wistar and Long Evans; data previously published [ 38]).
Using the cerebellum as reference region, no significant differences were found when comparing R1, k2 or BPND values between the different rat strains.
No significant differences were found when comparing R1, k2 or BPND values between the different rat strains; however, R1 values from Fischer, Wistar and Sprague Dawley rats were significantly different depending on the reference region selected for calculations in SRTM.
Furthermore, differences in the radioactivity concentrations expressed in %ID/cc or SUVs in the tumour were observed between the different rat strains regardless of body weight.
In order to find functional connections between different QTLs, we selected data from two different rat strains susceptible to collagen-induced arthritis (DA and BB/Dr) crossed with the same arthritis resistant rat strain (BN).
The results are remarkable: TCDD induces wide-spread alterations in mRNA abundance, but only a very small fraction of these changes are conserved between mouse or rat and, as demonstrated here, within different rat strains.
With regard to behavior of rat strains and arthritis susceptibility, experiments in different rat strains (DA rats, LEW rats, AO rats, PVG rats, outbred Wistar rats) indicated that the development of arthritis and severity of the disease upon Mtb injection correlated well with specific behavioral patterns of the rat strains [ 55].
The two stimulus animals used for each paradigm were always from different rat strains.
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