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When differences between different outcome groups were compared, if the data were normally distributed the unpaired t test was used.
Levels of ESR were not significantly different between different outcome groups.
Comparisons between different outcome groups for gender and autoantibody status were carried out using the chi-square test.
Articles by Mussack and colleagues [ 19] and Hachimi-Idrissi and colleagues [ 15] were excluded from further review because they reported serum levels of S-100B in patients with CA after CPR but without comparison between different outcome groups.
Reisinger and colleagues [ 21] assayed serum NSE concentrations at five different time points after CPR (from ICU admission to day 4), although without statistical comparison between different outcome groups, to determine the cut-off value for peak NSE concentration within these five points predictive of 'persistent coma (CPC 4)' with a specificity of 100%.
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There was no evidence of a difference in total stress, total PA or total NA between the test and the control groups or between the different outcome groups and no evidence of a change in levels over time.
This paper reports on the use of an associative data mining approach [ 15] to reveal evidence-based associations between combinations of variables and different outcome groups: African American CRCS adherent and non-adherent participants.
Ethnic groups and gender were not different between outcome groups.
To investigate differences between the different treatment outcome groups, ANOVAs or Chi-Square-Tests with post-hoc tests were calculated.
The only significantly different outcome between groups was the duration of acute pain (3.8 days for combined treatment vs 5.5 days for valacyclovir only); furthermore, a lower incidence of pain persistence during follow-up was reported for patients undergoing combined treatment (26.7 vs 53.3%), although no definition was provided neither for PHN nor for the duration of follow-up [ 32].
The second highest quality evidence is from randomized controlled trials where researchers can be confident that the intervention, not underlying differences between groups is the cause of different outcomes between groups.
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CEO of Professional Science Editing for Scientists @ prosciediting.com