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The regions of sequence similarity between different mouse proteins are summarised in Additional File 1: Figure S1.
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For the analysis, we selected eight different mouse protein-coding genes covering different cellular functions.
In addition, our ability to identify protein biomarkers conserved between different mouse models of SMA and human SMA patients suggests that common biomarkers can be utilized in both pre-clinical testing of new treatments in animal models as well as in human clinical trials.
When comparing α7R expression between different mouse strains, α7R gene expression does not correlate with protein levels [ 37].
There is some unexplained variability in the values between groups of mice and between different mouse strains.
We assembled 94906 pairwise eukaryotic protein-protein interactions from BIND, DIP [ 29], HPRD, MINT [ 30], Mpact [ 31] and MPPI [ 32]. 29074 of those interactions were between different proteins from human, mouse or rat and were used in this study.
The similar phenotypes observed between genetically different NCL mouse models, and the potential for interactions between different NCL proteins, suggest that shared or convergent disease mechanisms might underlie the different forms of the disease.
(F ) Norrin discriminates between different FzCRD proteins.
Such GTPase reporter mice will facilitate future comparisons between different small G proteins tremendously, and different strains will doubtless prove appropriate for different applications.
Clustering indicates high and separation low compositional similarity between the different mice.
Changes between M-protein and myomesin-3 expression might discriminate between different DCM mouse models ↑ up-regulation, ↓ slight down-regulation, –: no alteration detectable The M-band protein composition is identical in embryonic heart of mouse and human and is restricted to the EH-myomesin isoform.
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