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Sharing a platform between different models is a better investment than building just a few hundred thousand of each one on bespoke platforms.

The degree of overlap between different models is shown in Supplemental Figs. S6 S8.

The test of differences between different models was carried out using a chi squared test.

The difference in C-indices between different models was assessed using the method described by Haibe-Kains et al [20].

The significance of a difference in C-index between different models was calculated using the method described by Haibe-Kains et al. [12].

To this aim, the decoding accuracies between different models were compared using a pairwise t-test using a Bonferroni correction.

With the integrative approach, the linkages between different models are represented in three dimensions so that interacting with one model's components provides context for the other model's components through a method of highlighting.

A comparison between different models was presented in [13].

Discrimination between different models was made by comparison of the objective function.

Discrimination between different models was made by comparison of the OFV (−2 log likelihood (OVF)).

Choices between different models are based on the Deviance Information Criterion (DIC) (Spiegelhalter et al., 2002), which is a generalisation of AIC (Akaike, 1974) suitable for application to hierarchical models.