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In order to perform their functions effectively and efficiently, enzymes undergo conformational changes between different functional states.
Using molecular simulations, we observe equivalent correlated motions in β-sheet-rich proteins and show that these are associated both with their collective equilibrium fluctuations and with structural transitions between different functional states.
However, the large motion that Pf-cTrpRS undergoes during transitions between different functional states avails an opportunity to arrive at compounds which selectively perturb the motion, and may provide a starting point for the development of new anti-malaria therapeutics.
The work has not only led to the definition of the first structural constrains in the tertiary structure of this class of transporters, but also allowed inferences about conformational changes accompanying substrate translocation and residues critical for regulating the equilibrium between different functional states in the transport cycle.
The second is the chromatin level, which allows switching between different functional states.
Cell-graphs previously used to distinguish between different functional states in 2D histopathological slides of brain, breast and bone tissues with up to 98 and 84 and 90 percent accuracy [25] [27].
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"The brain only has limited energy at its disposal and it appears that it must choose between two different functional states - awake and aware or asleep and cleaning up," said researcher Dr Maiken Nedergaard.
Transfer of the sulfuryl group (-SO3) to and from small-molecule metabolites switches these compounds between distinctly different functional states.
Conversely, 3D contact probability was depleted between regions with different functional states.
From a clinical perspective, the present study demonstrates that these new accelerometry parameters play an important role in differentiating between subjects with different functional states.
Three different functional states: compensated, subcompensated and decompensated were specified depending on the DCP level.
More suggestions(17)
between fundamental functional states
between different functional centers
between different stable states
between different transcriptional states
between different functional groups
between different functional areas
between different functional units
between different functional oscillations
between different functional shapes
between different functional clusters
between different functional modules
between different functional classes
between different functional forms
between different functional subgroups
between different functional outcomes
between different functional categories
between different functional regions
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