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For exploring superfamily diversity in the CATH-Gene3D resource, we have used an approach that searches for SDPs to distinguish between different functional clusters [ 22].
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Subsequent clustering identified at least three different functional clusters.
Note that individual genes may be annotated within several different functional clusters.
To examine the different functional clusters in these two phases, categories of the GO database were analyzed.
I found that different functional gene clusters have different spatial distributions of TFBSs, indicating that gene regulation mechanisms may be very different among different functional gene clusters.
I found that different functional gene clusters have different spatial distributions of the TFBSs.
In summary, my results show that different functional gene clusters have different spatial distributions of the TFBSs, indicating that gene regulation mechanisms may be very different among different functional gene clusters.
Moreover, I used my method to construct the spatial distributions of the TFBSs for different functional gene clusters.
These clusters contain proteins in different functional classes; one cluster in VZV contains proteins involved in virion assembly, nucleotide repair, metabolism, and host-virus interaction.
There's some aspect of that, but people really need to think in a broader way about the relationships and connections between the different functional areas of business.
We found significant evidence of type I functional divergence for comparisons between different gene clusters (θ I = 0.23 ~0.40, P < 0.01; Table 3); namely, there were some amino acid sites with discrepancies in their evolutionary rate between these paralogous pairs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com