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The fold change (log2) showed larger divergence between different clustered or homologous miRNA species and between different individuals.
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Thus, these two terms cancel the difference between different cluster pairs and we can treat them equally.
As described by Girvan and Newman [27], if a network contains clusters that are loosely connected by a small number of edges, then edges connecting clusters have a high edge betweenness, because all shortest paths between different clusters must go along these edges.
Finally, family interaction types were defined based on the results of one way ANOVA which showed differences in each factor between different clusters.
Standardized weights were assigned to the data to account for differences in selection probabilities between different clusters of MSM arising from the sampling design [ 7, 11]; clusters were also taken into account, using the Complex Samples module in SPSS.
Results indicate that there are significant differences in copy number and mutation status between different clustering categories (Additional file 4).
When the frequency or percentage of inclusion of treatments in the NEMLs for various types of breast cancer was compared between different clusters of countries, non-parametric tests were used to investigate the differences among groups, namely the Kruskal Wallis test for geographic regions and income levels as well as the Chi square test for recent versus older NEMLs.
(2001) had been used to find the optimal number of clusters, depending on the gap between different clusters.
Moreover, it lacks a proper evaluation that considers demanding node mobility, with nodes constantly changing between different clusters.
The smaller the area of the clusters indicated the better the reproducibility, and the larger the distance between different clusters indicated the better the discrimination.
However, a major drawback of these solutions is related with inter-cluster routing overhead and poor support of node mobility between different clusters.
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