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The heatmap pattern also demonstrates that, although most of the proteins showed similar expression pattern, proteomic differences existed between different clinical subgroups of rabies patients.
The known groups validity supported the ability of the PRUNE to discriminate between different clinical subgroups like those who have/have not improved following surgery, or able/not able to return to work.
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Therefore, we investigated whether there were differences in the expression of genes involved in the inflammatory response and AMP production between the different clinical subgroups.
As and when these findings are validated in other cohorts it will be important to combine data in order to improve power and accurately determine whether the associations seen are consistent between the different clinical subgroups of JIA.
Besides, differences of onset age might represent different clinical subgroups.
Moreover, CpG methylation profiles characterize different clinical subgroups and strongly correlate with outcome[ 40, 41].
However, the components of acid – base disturbances are kept proportionally constant among different clinical outcome subgroups.
Two explanatory subgroup analyses are planned to evaluate whether there are indications that treatment effects differ between clinical subgroups.
The BSIqol was capable of discriminating between clinical subgroups, with different ECOG-PS and work activity.
However, not all FACT-Ga scores showed statistical significance in the comparisons between clinical subgroups.
There were not differences between different subgroups.
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