It has been reported that E2 protects cells from hypoxic insult in different cell contexts [40] [42].
MTX has been reported to suppress NF-κB activity in a different cell context [ 35].
Thus, the regulatory effects of neurotrophins on cell phenotype are not fully determined by the Trk receptors that they activate; rather, they can vary with differences in cell context that arise not only between different cell lineages, but also between individual cells of clonal relation.
In the context of biological samples, the Raman spectral information has been used to classify between different cell lines [1,2], or detect cancerous cells or tissue [3,4], among many other applications.
Mitochondrial heterogeneity within and between different cell types.
In the context of mutual relationships between different cells of the neurovascular unit, endothelial cells of microvessels have shown to provide trophic support for OPCs [ 147].
We show that senescent salamander cells secrete many factors, which have been reported to be secreted by mammalian senescent cells in various contexts (as SASPs differ between different species, cell types and modes of senescence).
In this context, therapeutic applications of adult stem cells to aged or pathological tissue repair in the context of regenerative medicine will require an increased understanding of stem-cell biology, of the cross-talk between the different cell types involved and of the environment of the ageing or pathological tissue.
The relationship between c-Myc, Sall2, and Noxa is not straightforward because studies are from different cell types and context.
