Likewise, post-mortem factors such as the agonal state, post-mortem interval between death and sample extraction, or sample pH may further degrade potential expression signals.
Most notably, samples derived from autopsy may not represent processes active in life, findings may be influenced by cause of death, samples tend to be derived from older individuals and thus may misrepresent natural history over the course of disease, and histopathology may be affected by the interval between death and sample collection (that is, PMI).
The time span between death and tissue sampling was less than 12 hours in eight and less than 24 hours in two dogs.
It was realized that PM drug concentrations are not necessarily the same as those at the time of death, as drug levels may vary according to the sampling site and the interval between death and specimen collection (PM interval).
The sample size in our study was most likely too small to reveal a significant relationship between death and MCS.
However, in an examination of the impact of the length of time elapsed between death and dropout on model results, we conducted a sensitivity analysis excluding from analysis individuals who were last interviewed 5 (79% of sample), 7 (88% of sample) and 10 years before death (93% of sample).
This article provides evocative and empathic lifeworld descriptions contributing to a deeper understanding of these elderly people and raises questions about a close association between death wishes and depression in this sample.
It is likely that differences in hepatic CYP1A1 expression simply reflect degradation and the difference between time of death and fixation for samples collected from subsistence hunts and strandings.
Those samples were not used for the microarray experiments since significant transcriptomic changes might have occurred between the time of death and the time of sampling.
The postmortem interval (PMI) was defined as hours between time of death and time when tissue samples were frozen.
