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The team tried different algorithms before having a "major breakthrough" in 2009, when they finally achieved the right balance between coverage and accuracy, the two things proofreading software has to balance.
MV and our method returned a list of residues (or patches) with decreasing prediction scores and allowed users to tradeoff between coverage and accuracy by choosing a threshold.
There is often a trade-off between coverage and accuracy and therefore one must decide how conservative a set to use.
When the union of the top 3 patches is used to predict DNA-binding sites, coverage increases to 42%, but accuracy decreases to 72%. Figure 2 shows the tradeoff between coverage and accuracy when multiple top-ranking patches are used.
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Figure 2b and c shows a similar relationship between coverage depth and accuracy for higher MAFs.
Specifically, interaction datasets of sufficiently high coverage and accuracy would reveal the (real) relationship between expression and number of interactions, as well as the relationship between evolutionary rate and number of interactions.
These limit prediction coverage and accuracy particularly for non-binders.
This will have an impact on coverage and accuracy.
To improve the image coverage and accuracy, we use a mathematical non-linear optimization with constraints.
Information quality can be analyzed in terms of the level of detail, coverage, and accuracy.
To evaluate the quality of the interaction data, coverage and accuracy were calculated as follows.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com