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The investigation of eventual relationships between cortical changes and WM lesion load in CADASIL was the other target of our study.
These results highlight the possible mechanistic link between cortical changes and modified motor behavior in people with knee OA.
A recent study has found a correlation between cortical changes and inappropriate response to noxious stimuli, altered body perception and psychological and cognitive manifestations [ 11].
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Alternatively, the contrast between the in utero cortical changes reported by Chenn and Walsh and the lack of a CNS phenotype in our mice or those of Fults could indicate that the developmental stage of the neuroepithelial cells in which stabilized β-catenin is expressed is critical.
To focus on the connectivity changes between cortical and subcortical regions and on the module changes of subcortical regions, only connections between cortical and subcortical regions and between subcortical regions were shown.
Furthermore, proportionality was reported between the absolute performance level and the observed cortical changes (Elbert et al 1995b; Buonomano and Merzenich 1998; Dinse and Merzenich 2002).
Previous research demonstrates the capacity for fNIRS to detect cortical changes to varying speech intelligibility, revealing a positive relationship between cortical activation amplitude and speech perception score.
The relationship between reorganisation of the motor cortex and modified motor behaviour in musculoskeletal conditions has led to speculation about the functional significance of the cortical changes.
The cortical changes identified histopathologically ranged from one to several gyri in one to six tissue blocks (equivalent to between ≤5 mm and approximately 30 mm).
Our measures highlight a clear tract-specific relationship between cortical neurodegeneration and diffuse changes in myelination in non-lesional tract white matter.
Lerch et al. [58] also proposed a link between histopathologically confirmed changes and cortical atrophy assessed through cortical thickness measurement.
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