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These findings support the association between conventional lung function tests and the AUC CV > 20%) value.
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We also concluded that the use of conventional lung function testing alone was unable to delineate between patients with EM alone and those with EM plus phenotypes.
However, the potential effect of such aerosols cannot be fully evaluated by conventional lung function tests because these are insensitive to peripheral lung structure.
Therefore, conventional lung function tests (spirometry) are insensitive [5].
The results suggest that our present SPECT method has the capacity to identify minor lung function abnormalities earlier in a disease process than conventional lung function tests.
Using the adapted CVT method, with the newly implemented compensation technique, we showed that patients with lung function abnormalities detected by conventional lung function tests generated significantly higher AUC CV > 20%) values compared to healthy subjects with normal lung function tests (p = 0.006).
Conventional lung function techniques such as spirometry are considered to be not sensitive enough to detect small airway malfunction [3]; [6]–[8].
Diagnosing asthma is difficult in preschool children due to the nonspecific symptoms and because conventional lung function tests cannot be carried out [ 7].
The relationship between restrictive lung function impairment and heart diseases is still poorly studied on a population level.
Associations between all lung function metrics and PM10 were positive but with wide confidence intervals.
All of the conventional measures of lung function (FEV1, D lco/V a, RV, and FEV1/FVC) were reliable in distinguishing between EM only and EM plus BE and/or BWT (EM + BE/BWT), with receiver operator characteristic curves of < 0.6 (Fig 3).
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