In conclusion, by comparing the transcriptomes of normal contralateral tissues of PTC occurring in children exposed and non-exposed to the Chernobyl fallout, we have identified a gene expression signature that permits discrimination between both cohorts.
However, we believe that this technical limitation might not be influencing our final results since comparisons have been performed with contralateral tissue of the same individuals.
95% of the IR genes expressed only in ipsilateral tissues increase in expression while 74% of the IR genes expressed only in contralateral tissues decrease in expression.
Intriguingly, modified eBURST analysis revealed in both mice several connections between single cell clones derived from distant tissues (such as from contralateral tissues), suggesting that cell migration may occur during development, such that spatially separated cells share similar mutation profiles.
It would be reasonable, in patients with a supratentorial, unilateral lesion, to expect a difference in tissue pressure at the site of the mass compared with the contralateral tissue pressure, but what do we know of differences between tissue and the ventricle with or without mass lesions, or even the effect of tissue decompression on differences between tissue or ventricular pressure readings.
In this manner, the right flank of the animal served as reference region as this contralateral tissue is the same except that it is devoid of tumor cells.
Normal looking (contralateral tissue was unstained.
The mean tHb levels of lesions were 27.6% higher than those in the surrounding normal tissue and 24.6% higher than those in the contralateral tissue.
In this study, HRBECs were derived from the unafflicted contralateral breast tissue of 23 individual volunteers (mean age 58, range 40 81 years).
This pilot study demonstrated that there was no statistically significant difference in physeal plate diameters between contralateral extremities and the degree of variation between contralateral extremities was minimal.
