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One possible link between complement activation and osteoblast/osteoclast functioning is supposed to be C5a with activating and chemotactic activity for these cells [ 9– 11].
The delicate balance which exists between complement activation and its regulation is altered in HIV infection and pregnancy disorders such as pre-eclampsia.
These results suggest that a balance between complement activation and regulation exists at the EC surface, and may impact vascular injury leading to thrombosis, arteriosclerosis, and atherogenesis.
Although a direct link between complement activation and autoimmune diseases has not been found, there is increasing evidence that complement activation significantly contributes to the pathogenesis of a large number of inflammatory diseases that may have autoimmune linkage.
In particular, the association between complement activation and the CFH risk haplotype which includes Y402H, a non-synonymous SNP in CFH which leads to a tyrosine to histidine exchange at position 402, is biologically plausible.
The multiple interplay of components of the classical and alternative complement pathway in association with the activated immune system provide a possible mechanistic link between photoreceptor-degeneration induced upregulation of CD74 activation in microglia and secondary vasoregression, but the causal relationship between complement activation and vasoregression needs further substantiation.
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We investigated the association between complement activation, coagulation and fibrinolysis systems, and postoperative excessive bleeding in cardiopulmonary bypass (CPB) surgery.
The association between complement activation in humans and adverse pregnancy outcomes is unclear.
No causal relationship has been established between complement activation on arterioles and LPHS but several case reports have described an association.
Numerous human and animal studies have affirmed the link between IRI, complement activation and tissue damage, for example in myocardial infarction.
Further support for the suggested association between abnormal complement activation and AMD came from a large case control study that revealed an association of AMD with diseases known to be associated with systemic complement activation [ 61].
More suggestions(15)
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