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Kaplan Meier survival analysis was used to compare risk of in-hospital mortality between comparator groups while censoring for patient discharge.
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23 Cohort studies are also prone to immortal time bias, which arises if the period participants are considered at risk differs between comparator groups.
There was no significant difference in CVD risk between comparator groups, whereas CVD risk at the 1-year follow-up was significantly lower than at baseline.
The sulfonylurea glimepiride was chosen rather than a placebo to ensure adequate glycemic control was maintained in the comparator group while preventing confounding of β-cell effects by use of other agents that affect insulin sensitivity.
12 13 Previous economic evaluations have demonstrated the cost-effectiveness of interventions that include manual therapy techniques compared with active comparator groups, 14– 16 while group-based cognitive behavioural treatments 9 and acupuncture care 17 have also provided acceptable cost-effectiveness estimates.
19 However, one issue with the change score method is that the "regression to the mean" effect could be substantially different between the comparator groups.
Trials published to date have not been designed to detect differences in clinical outcomes, and thus no significant differences between polypill and comparator groups have been reported.
Small reductions in body weight (<2 kg) were observed in all studies and were similar between saxagliptin and comparator groups.
In general, these baseline demographics and clinical characteristics were comparable between the linagliptin and comparator groups (Tables 1 and 2).
There were significant differences between the chemotherapy and comparator groups over time, despite comparable HRQoL at baseline.
Additionally, this was an open asymmetric study [ 6], where the comparator groups move to insulin while the rosiglitazone group has another oral agent added.
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