We assessed the association between common polymorphisms identified in the GSTM1, GSTT1, NAT1, and NAT2 genes and the risk of bladder cancer in two nested case-control studies within the Nurses Health Studyy (n = 78 female cases, 234 female controls) and the Health Professionals Follow-upp Study (n = 139 male cases, 293 male controls).
One possible explanation for the lack of consistent association between common polymorphisms and breast cancer risk in individual studies is that the change in risk associated with common variants is too low to detect in individual studies and results that are reported may reflect publication bias.
The aim of this study was to examine the association between common polymorphisms of the adiponectin gene (ADIPOQ) and microvascular complications in patients with type 2 diabetes mellitus (T2DM).
The difficulty in finding strong genetic association between common polymorphisms and DD was recently illustrated by the findings of the EU-funded project NeuroDys.
Our objective was to measure the interactions between common polymorphisms of P450 (CYP1B1, CYP2E1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC).
Mutations in PFN1 represent a novel mechanism underlying ALS, evidenced by the linkage of common polymorphisms in PFN1, tubulin A4A, dynactin, peripherin, and neurofilament genes to ALS10,11,12,13,14.
We used a case-only design, an approach not previously used to study gene environment interactions in PD, specifically to study interactions between glutathione-S-transferase (GST) gene polymorphisms and smoking in relation to PD. Four-hundred PD cases (age at onset: 60.0 ± 10.7 years) were genotyped for common polymorphisms in GSTM1, P1, T1 and Z1 using well-established methods.
We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes.
Common polymorphisms in genes responsible for vascular function, inflammation, and oxidative stress appear to modify associations between proximity to major roadways and LVM.
However, there has been conflicting evidence for associations between a common polymorphism in the mitochondrial genome (A10398G, G10398A in some prior reports) and breast cancer risk.
