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We documented the association between coagulation activation and organ dysfunction to investigate whether coagulation activation also plays a role in organ injury following cardiac surgery with CPB.
The interaction between coagulation activation and the inflammatory response is the characteristic pathological process of sepsis [ 33, 34].
The numerous interactions between coagulation activation and angiogenesis indicate that the latter is an integral part of the prothrombotic state in cancer [ 20, 22- 24].
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Sepsis induces an imbalance between exaggerated coagulation activation and inhibition of fibrinolysis.
In the study reported here, we prospectively studied the predictive association between biomarkers of coagulation activation and fibrinolysis (PAI-1, tPA and D-dimer) and development of AKI.
Cox-regression modeling was used to determine the association between elevations in the markers of coagulation activation and fibrinolysis and development of AKI.
Coagulation activation and alveolar fibrin deposition are common findings in ALI, and platelets are thought to be key contributors to the dysregulation of coagulation in ALI, through their role in coagulation and NET generation [169].
The aim of this study was to investigate the association between blood coagulation activation as measured by plasma d-dimers and lung function.
Thus, a clear causal relationship between glucose and coagulation activation could not be confirmed with the present study.
A significant difference in the ability to induce inflammatory and coagulation activation between endotoxin preparations of various microorganisms was also noted [ 14].
Heart failure (HF) is associated with coagulation activation, abnormal inflammation and endothelial dysfunction.
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