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The results showed that there was no correlation between clustering pattern and total toxin production (Figure 2).
To examine the basis for diploid-like clustering as observed in ~30% of the di-allelic SNPs, we examined the relationship between clustering pattern and genomic read depth.
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No associations between the clustering pattern and the clinical features were apparent.
Hierarchical clustering of the samples based on the DNA copy number changes showed no associations between the clustering pattern and the tumour subtype or the other clinical features (Figure 1), and no chromosomal regions with significantly different DNA copy number between the primary tumours and recurrences were found.
Finally, spatial clustering of BSE was observed in France [ 12, 13, 15, 22, 23] and some evidence was presented for correlations between the BSE clustering pattern and the density of pigs and/or poultry, consistent with the hypothesis that cross-contamination caused recycling of the BSE infection in French cattle born after a ban on MBM in ruminant feed [ 22].
Correlations between the clustering patterns and the ER status or the breast tumour phenotype were investigated using a Pearson χ test.
A fundamental difference between the above two clustering algorithms was that STEM pre-determines cluster patterns and, while it assigned all genes to clusters, it only designated some clusters as significant.
Most of the syntenic sequence blocks contained clusters of genes, resulting in high conservation of the gene clustering pattern between pepper and tobacco.
The combination of structural, phylogenetic and physical clustering pattern differences between YjeK and LAM enzymes were used to split the LAM family of proteins into two subfamilies that will be referred to as LAM and YjeK from hereon and suggest that these families have distinct functions, the first in lysine catabolism, the second related to EF-P.
The χ test was used to assess the relation between tumour grade and clustering pattern.
To analyze the relationship between total toxin production and clustering pattern, we measured the total toxin production in the strains from our collection using ELISA.
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