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We do, however, not expect that the effect observed during repaglinide treatment is based on an opposing effect of higher insulin levels ameliorating the deleterious effect of hyperglycemia since regression analysis did not exhibit an association between changes of insulin and FMD during the oGTT whereas a highly significant correlation was observed between changes of glucose and FMD.
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Insulin sensitivities at each time point, percentage changes of insulin sensitivity, mean blood glucose values, and SD and CV of blood glucose between the two groups were compared using Student t test.
For a fixed insulin concentration, a given percentage change of insulin sensitivity results in a proportional change to glucose disposal and thus glycemic level, all else equal.
2. Mathematical models to describe and tailor an individual patient's glucose sensitivity, the changes in glucose sensitivity over time and the relationship between changes in insulin sensitivity and the insulin/nutrition infusion protocol (amount of calories, access used for nutrition, amount and timing of insulin infusion) used in the individual patient.
Our study demonstrates a bidirectional inter-relationship between changes in insulin clearance and vascular endothelial function during the course of a weight loss program.
However, we found no correlation between (changes in) insulin sensitivity and mitochondrial function, although a parallel increase of both variables was seen upon exercise training.
Considering the correlation between insulin circulating levels and FF-leptin in NOW-PCOS, future studies should more closely focus on direct measurements of insulin sensitivity and insulin secretion in NOW-PCOS to better elucidate the relationship between changes in insulin secretion and/or action and changes in cytokines relevant to the fertility status in this population.
The DI adjusts for the interaction between changes in insulin sensitivity and insulin secretion as differences in insulin sensitivity must be balanced by reciprocal changes in insulin release in order to maintain glucose tolerance (and prevent hypoglycemia).
Also no relationship between changes in insulin sensitivity and ectopic lipids was found.
The relationships between change from baseline insulin sensitivity (1/fasting insulin in μU/mL) or HbA1c and measures of body composition included the baseline value of either insulin sensitivity or HbA1c as a covariate.
In the current study, despite demonstrating decreased insulin resistance after 6 months of metformin and increased insulin resistance with the OCP in overweight women with PCOS, we were unable to show any relationship between change in insulin resistance and RBP4.
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