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We also examined the association between changes in urinary N-telopeptide percentile and spinal bone mineral density (BMD).
However, group 1 had significantly less gain in BMD (P =.04) than group 2. No evidence of growth impairment was seen, and no association between changes in urinary N-telopeptide percentile and changes in BMD were noted.
In the same models, we also explored the association between changes in urinary arsenic between visits and the risk of mortality from cardiovascular disease.
Linear regression models were used to assess the relationship between changes in urinary 8-oxodG/8-oxoGuo and changes in diabetes-related variables and possible confounders of oxidative stress (albumin excretion, weight, blood pressure, HbA1c, GFR, and hemoglobin).
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Linear regression analysis was used to determine the relationship between baseline variables and changes in urinary 8-oxodG and 8-oxoGuo as well.
A K-PD model was also used for characterizing the PD of ibandronate owing to its PK complexity and substantial time dissociation between measured concentrations and changes in urinary excretion of the C-telopeptide of the α chain of type I collagen (uCTX, a marker of ibandronate activity).
We included changes in urinary arsenic between visits as a time dependent variable.
41 As exposure concentration might change in some participants from baseline, we calculated changes in urinary arsenic between visits using urinary creatinine adjusted arsenic.
Because arsenic exposures may have changed from baseline levels in some participants, we adjusted the final model (model 3) for changes in urinary arsenic between visits.
There were no significant associations between changes in 8-oxoGuo and changes in urinary albumin excretion, weight, blood pressure, HbA1c, GFR, and hemoglobin.
Changes in urinary indices between ICU admission (H0) and H24 are reported as the ratio between urinary indices at H0 by urinary indices at H24 Each patient was assessed during the first 6 hours following ICU admission.
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