Changes in lifespan between groups with identical genetic background and environmental conditions except for one defined difference can be used to demonstrate the effect of this factor on survival.
Moreover, we could not assess the relations between changes in modifiable factors over the lifespan and survival because we assessed exposures only at baseline.
Another proposal is to raise the normal retirement age to 70 and then index it to future changes in lifespan.
Aβ1 40 flies show no obvious rapamycin-dependent changes in lifespan.
Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models.
Finally, cells deleted for a short chain dehydrogenase gene (SPAC521.03) showed no changes in lifespan.
Such future experiments will likely clarify the physiological role of to in affecting diet induced changes in lifespan.
Only mutant females showed significant changes in lifespan compared to controls, with opposite effect seen in unmated and mated females.
This code is functional because daf-7 and tph-1 mutations bidirectionally attenuate food level-dependent changes in lifespan.
