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We did not find any significant association between changes in inflammatory markers and statin therapy.
We therefore focused attention on the relationship between changes in inflammatory parameters and changes in pulse pressure.
The ASSERT study was primarily designed to evaluate the safety and efficacy of infliximab in patients with AS and was not powered to evaluate correlations between changes in inflammatory markers and clinical measures.
Longitudinal studies revealed no correlation between changes in inflammatory markers and changes in endothelial function [ 12, 13], and the improvement in microvascular endothelial function after treatment occurred without any change in inflammatory markers [ 14].
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However, none of the analysed retrospective studies that assessed the effect of statins on outcomes in COPD has examined the correlation between change in inflammatory markers and those outcomes.
Two previous studies on the relationships between the meal-induced changes in inflammatory markers relative to plasma triglycerides and glucose have also shown mixed results in patients with Type 2 diabetes.
Balanced against these limitations, the main strength of our study is its longitudinal design, which enables us to suggest a cause-effect relationship between changes in dietary phylloquinone intake and changes in inflammatory and related metabolic risk markers.
Although we observed a modest improvement in post-meal plasma and chylomicron triglyceride concentrations with pre-meal prandial + basal over the first 3 h of the post-meal period, we did not see a relationship between changes in plasma triglyceride concentrations and changes in inflammatory markers or glycative stress.
At baseline, the levels of CRP, IL-1Ra, IL-6, TNFR1, and TNFR2 did not differ significantly between statin users (n = 46) and non-statin users (n = 15), neither did changes in inflammatory markers differ between statin and non-statin users after 6 months.
We then analyzed the relationship between the degree of lowering of HbA1c and blood pressure and changes in inflammatory factors.
Furthermore, the relationship between pulse pressure and the degree of lowering of HbA1c and changes in inflammatory factors was analyzed.
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