Sentence examples for between cell types the from inspiring English sources

However, for drug pairs whose interactions vary between cell types, the selectivity of the combination diverged from what is anticipated from its component drugs.

By generating maps of histone modifications at promoters and enhancers in several different human cell lines, it has been possible to determine that although modification patterns at promoters are largely invariant between cell types, the patterns at most enhancers are specific to a single cell type and correlate well with cell-type-specific gene expression.

For normalization of the data between cell types, the relative promoter activities were expressed as log2 [(1+ Firefly luciferase/Renilla luciferase)/Average of the negative control] [11].

Despite this variability between cell types, the non-calcemic 20(OH)D3 and its hydroxyl-derivatives generally exerted effects on cell proliferation and differentiation comparable to those of 1,25(OH)2D3.

Despite these differences between cell types, the effects of HIF-α knock-down or removal of the putative HREs in the promoter constructs were identical: Neither knock-down of the HIF-α subunits nor deletion of the putative HREs altered the response to DMOG, DP or hypoxia (Figure 4C D).

The greater the biological similarity between cell types, the greater the overlap in MAE genes.

Here although there was some variation in the magnitude of response between cells types, the trend/activation profile was similar to the primary cells in all three cholangiocarcinoma cell lines (figure 3).

Some of these factors could potentially affect the actual expression of the genes by the target, such as cell-cell interactions between cell types within the mixture.

The relationship between methylation changes between cell types and the divergence in methylation levels observed between paralogous sites was modeled using multiple linear regression.

Extending this idea, it has been debated that it is not synergy itself that is pharmacologically useful, but differential drug interactions between cell types, with the essential goal being a more favorable interaction on the target cell type than on non-target cell types15,16,17.

Strikingly different protein bands are observed for the same cell type with different antibodies and between cell types with the same antibody.