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In contrast, it has also been reported that COX-2 expression induced by epidermal growth factor is unaffected by JNK inhibition in astrocytes, emphasizing the differences between cell types as well as the inflammatory stimuli used for investigation of signal transduction pathways [ 68].
Evidently, proteins that belong to a same functional ontology are likely to be co-regulated though their absolute levels might vary between cell types; as second criterion, proteins were selected that were systematically co-regulated with proteins belonging to a different functional ontology.
Locus-specific chromatin architecture varies between cell types, as genes are differentially expressed among different cells at specified times.
Proliferating N- and S-type cells had similar SOCE profiles yet clearly the composition of proteins varies between cell types as Orai1 expression was generally lower in S-type cells and TRPC1 was not present.
Within the shoot, ion allocation can vary between cell types as found in mesophyll and epidermis of barley and wheat, where differences for K+ and Cl- were measured [ 4, 5].
For lineage relationship, we employed a principal components analysis of array datasets to characterize the relatedness between cell types as defined by their transcriptomes, i.e., the entire repertoire of expressed genes.
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The penetration of the cell membrane into patterned micro-holes could be analyzed quantitatively, indicating a significant difference between the two cell types as well as between different cell adhesion areas.
The length of linker DNA varies between species and cell types, as well as during differentiation and gene activation [7], [8], [9].
Target genes regulated by the HH signaling pathway differ between tissues and cell types, as well as being influenced by the presence or absence of regulatory factors co-expressed with GLI proteins that eventually determine the transcriptional programs activated by HH signaling [6], [37].
An FDR cutoff of 10%% was applied to the results of each method to produce sets of disease cell-type associations The GSC methodisease cell-type-chassociationsassociaThens between diseases and cell types, as well as associations that warrant further study.
The Opa proteins have different binding affinities to heparan sulphate and CD66-family proteins and are able to cause intimate adhesion between meningococci and several cell types, as well as influencing binding of capsulate bacteria [54] [60].
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