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First, there is a high correlation between cell lines sharing the same tissue origin.
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Interestingly, when T47D and MCF-7 cells are exposed to E2, the expression profiles between both cell lines shared several regulated genes and are similar, and some of them overlap with genes expressed in ERα-positive tumors [ 133].
The W1DR and W1VR cell lines shared similar levels of resistance to doxorubicin, vincristine, and paclitaxel.
Furthermore, the OHT and ICI cell lines shared similar yet holded unique association patterns.
However, not all normal or malignant cell lines share all characteristics with embryonic epithelia.
We found low concordance between the NCI60 and the CCLE sensitivity data (Supplementary Fig. S13), and we did not obtain a high correlation between the predictions calculated with a model trained on the NCI60 data for eight drugs on 44 cell lines shared by the CCLE and the subset of the NCI60 cell lines considered here.
Most cancer cells in the SCLC NCI-H446 cell line shared the phenotypic characteristics of both neuroectoderm and mesoderm lineages.
Most HCC tumors and cell lines share remarkably similar gene expression profiles.
Reasonably this cell line share some but not all of features of primary osteoblasts [ 28].
The clone-by-clone comparison of DNA copy numbers between cell lines and tumor tissues allowed detection of recurrent DCNAs exclusively in breast cancer cell lines as well as recurrent DCNAs shared by two groups.
The comparison of CGH profiles between cell lines and tumor tissues revealed gains of 1q and 8q and losses of 8p, 11q, 16q and 17p as recurrent DCNAs shared by two groups.
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