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More evidence is becoming available that demonstrates the interconnection between cell cycle deregulation and tumor development [ 9].
Because of the reported possible interactions between cell cycle deregulation and tumor development [ 9], we investigated the effect of SST on the cell cycle using the gallbladder cancer cell line GBC-SD grown to the exponential growth phase.
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In addition, interactions between HR-HPV oncoproteins and endogenous cellular proteins have been shown to trigger cell cycle deregulation, a critical component in the progression to cancer [ 40].
Monti, S. et al. Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.
The cell cycle deregulation leads to neurogeneration.
As described in the previous sections, cancer cells exhibit critical metabolic transformations induced by mutations that result in cell cycle deregulation associated with enhanced cellular stress.
CDKs (CDK1, CDK2, and CDK5) have been associated with tau hyperphosphorylation, amyloid precursor protein processing, and apoptosis due to the cell cycle deregulation in AD [31].
It is known that cell cycle deregulation is a general feature of malignancy.
Genetic evidence indicates that stat92E contributes to cell cycle deregulation and excess cell size phenotypes that are observed among ept mutant cells.
Our observations have potential implications for future therapeutic strategies based on targeting of cell cycle deregulation such as via cyclin-dependent kinase (CDK) inhibition.
However, mutations in the p53 gene can induce cell cycle deregulation and apoptosis in cancer cells.
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