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The relationship between carcinogenesis and changes in specific gene expression or genome stability has been well documented [ 3- 6].
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Numerous studies have reported the relation between carcinogenesis and the cell-cycle-related gene [ 3- 6].
It has been suggested that there is a close relationship between the carcinogenesis and the dysregulation of Notch degradation.
Deregulated expression of miRNAs has been observed in cervical carcinogenesis and appears only partly related to chromosomal changes.
Carcinogenesis and tumor progression are accompanied by both genomic and epigenomic changes, equivalent to alterations of the chromatin texture.
It is important to describe the general changes, in different levels of the nuclear structure and organization, during carcinogenesis and tumor progression and to look for differences between nuclei of neoplasias with a good or a bad prognosis.
Eph ephrin interactions control the signal transduction between cells and play an important role in carcinogenesis and other diseases.
Despite these improvements in technology, the timing and relationship between genetic and epigenetic changes that occur during the process of carcinogenesis are still unclear.
Aging, Carcinogenesis and Radiation Biology.
P21 andp27: roles in carcinogenesis and drug resistance.
Floyd R A. Role of oxygen free radicals in carcinogenesis and brain ischemia.
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