The timing of HIV infection was estimated with the same level of precision in both studies, with short intervals between study visits when HIV testing of children was performed.
Further, if a study participant purportedly away from their place of residence in between their study visits, attempts were made to trace them to their new locations using the provided contact information.
All consultations between scheduled study visits, as well as changes in treatment, will be recorded.
Persistence of effect of MBSR on BP will be assessed using repeated analysis of variance measures, comparing group differences between subsequent study visits (baseline, pre-MBSR, post-MBSR and study close-out).
The clock times of midazolam administration differed for each study visit, so that data were collected at six different timepoints throughout the 24-hour period (oral administration at 10 00, 14 00, 18 00, 22 00, 02 00, and 06:00) in each of the 12 volunteers, with a washout period of at least 2 weeks between the study visits.
The decrease shown in Fig. 1 can be either an overestimation or an underestimation, as patients with sustained (drug-free) remission are more likely to drop out [ 20] and, although patients were instructed to visit their rheumatologist at the moment of a flare, flares between two study visits might have been missed.
A retrospective analysis of clinical trials conducted between 1992 and 1999 concluded that the interval between study visits could not be safely increased because significant numbers of drug toxicities would have been missed [12].
Within group changes, between-group differences in overall course and between-group differences at study visits were analyzed using a linear model that takes repeated measures into account (Proc Mixed in SAS), with correction for differences in baseline values.
In case of such regimen changes between study visits, the lowest recorded compliance level was used for analyses.
Some patients were prescribed a number of different drug regimens during the 3- or 6-month intervals between study visits and therefore had more than one compliance rating recorded at the corresponding visits.
