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Kaplan-Meier survival analysis demonstrated a significant difference between both genotypes in the course of the KA treatment (Fig. 4C, p = 0.0494, log rank test).
Expression levels of all these genes did not differ between both genotypes in F4/80(lo)Ly-6C(hi) subset (not shown).
In tsp-1−/− mice, postischemic capillary density was further increased in the infiltrated area compared to wt mice (fig. 4E), whereas no difference was found between both genotypes in areas which were not infiltrated by macrophages, as well as in non ischemic tissues.
We could not detect any difference between both genotypes in membrane potential, firing frequency and action potential shape of cerebellar PCs.
Differences in transcriptional regulation at the adrenal gland could already exist between both genotypes in basal conditions because basal cortisol levels are typically greater in MS pigs.
We also compared the total number of intercalations between WT and MZ spg in each time window, and find that while there are significantly less intercalations in MZ spg during time windows T1 and T2, the intercalation rate is similar between both genotypes in time window T3 (supplementary material Fig. S4B).
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The greatest metabolic change occurred between 21 to 28 DPA in both genotypes, in contrast to the decrease in transcriptional complexity in the same interval.
We identified the up-regulation of five genes encoding the catalytic subunit of cellulose synthase (CESA) between both genotypes: four in Cashel-P and one in IRL-OP-02538-P.
Clear differences between both genotypes existed in their response to Microcystis stress.
Such a plot does not present the complex relationships that exist between both genotypes and phenotypes in PheWAS.
We report changes in the 2-DE map between both genotypes as well as in response to parasite infection.
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