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Direct comparisons between bisphosphonates are difficult because of differences in study methodology.
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The most common reason cited by patients for their nonadherence is that the strict dosing instructions for bisphosphonates are difficult to follow.
Cross-country comparisons between PHPs are difficult.
Comparisons between studies were difficult.
But alendronate and most of the other bisphosphonates are pills that are very difficult to take because they can irritate the esophagus.
Telling between these two possibilities is difficult.
Although the enhanced bone resorption can be inhibited by a treatment with bisphosphonates [4], [5], it has been difficult to stimulate the unloading-induced suppression of bone formation.
The independent association between treatment choice and prescription of paraclinical investigations was unexpected, but may indicate greater use of monthly bisphosphonates in patients whose osteoporosis was difficult to manage.
Most often, it is associated with bisphosphonates given intravenously, not taken by mouth (as most bisphosphonates are).
And the problems with Bisphosphonates are NOT rare.
Bisphosphonates are effective in preventing osteoporotic fractures.
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