This overview aims to synthesise and critically evaluate the quality of SRs and current primary studies assessing the relationship between occupational biomechanical factors and CTS in working populations.
However, since pain severity has been found to be more closely linked to MRI features than to CR features [ 47], we were surprised by the limited amount of significant associations between MRI features, biomechanical factors and physical examination findings.
Thirdly, our study design was cross-sectional with no control group, while a longitudinal design, preferably using a control group of patients at risk, is necessary to unravel interactions between tissue abnormalities, biomechanical factors and physical examination findings.
This is the first knee OA study exploring associations between multiple tissue abnormalities, biomechanical factors and physical examination findings.
However, early systematic reviews (SRs) concluded that there is sufficient evidence for an association between occupational exposure to biomechanical factors and the development of CTS [ 1, 10, 21, 22].
In conclusion, there is limited knowledge on the association between OA-related tissue abnormalities, biomechanical factors and physical examination findings in knee OA.
The discipline will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics.
The latter observation was associated with differences in signalling pathways, and suggests important differences in the endothelial response to biomechanical factors between the aorta and the aortic valve.
Only a few studies have been performed on the association between tissue abnormalities and biomechanical factors.
