Also, considering that phenotype change or disease results from dysregulation of complex relationships between biological components [ 25, 26], a strict cutoff usage in single gene analysis can miss signal flow.
The assessment of genome function requires a mapping between genome-derived entities and biochemical reactions, and the biomedical literature represents a rich source of information about reactions between biological components.
The large sample number allows to infer co-expression and co-regulation networks for identification of unknown associations and dynamic interactions between biological components.
Most models in this category are kinetic models that describe and quantify interactions between biological components.
Finally, future research should focus on better elucidating relationships between HA and other biological components of the ecosystem.
This requires recognition of the complex interactions between the chemical, physical and biological components of an ecosystem [ 22, 72- 74] through a combination of empirical studies, long-term observational data and ecological modelling [ 64, 72, 75].
A second type of methodology compares biological components of fitness, such as mating competition, longevity, and reproductive output, between populations of interest [ 1, 11].
Rustichini notes that some scientists believe that all the biological components of competitiveness, taken together, comprise 40% of the explanation.
