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For pathway crosstalk, we considered both common proteins (nodes) and common interactions (edges) between any two pathways.
Specifically, we examined crosstalk among these pathways by computing overlap scores based upon shared genes between any two pathways, and represented them graphically using Cytoscape.
However, Figure 8 shows that the average overlap between any two pathways also increases significantly.
No significant correlation in FC contamination between any two pathways was found (Table 3).
Fraction of overlapping genes between any two pathways is represented by the edge thickness, with cutoff overlap coefficient of 0.1.
Transcription-mediated cross-talks can be identified between any two pathways or globally at the systems-level.
Similar(53)
Prompted by similarities in the eye phenotypes of RA and Wnt pathway mutant mice, investigators have determined whether there is any regulatory linkage between the two pathways.
The total energy of the system was defined in terms of the distance of each pathway from the center, overlapped areas between two pathways, and between a pathway and the periphery of the figure (see Text S1).
Intriguingly, ABA signaling inhibits the BR signaling pathway after BR perception, and crosstalk between the two pathways upstream of the BRASSINOSTEROID-INSENSITIVE 2 (BIN2) kinase has been reported27,28.
Furthermore, no direct comparison has been made between formation times, nor has the branching ratio between the two pathways been examined under strong-field conditions.
But the reason why there are two pathways (K and D pathways) responsible for oxygen reduction is not clear, and the functional difference between these two pathways is not know either (Fig. 1).
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