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In two independant cohorts of colon cancer patients, we observed an association between an increased recurrence risk and the reduced expression of a GPS.
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Different groups describe a positive association between DTCs in bone marrow and an increased recurrence rate or reduced survival while other found no association between DTCs and prognostic factors [ 6].
However, when analyzing prognostic features of Chk1 in untreated premenopausal breast cancer patients, we did not observe any link between Chk1 and increased recurrence rate.
Poor endurance of the multifidus is a predictor of increased recurrence of LBP.
Those with diabetes showed worsened overall survival compared with those without diabetes in univariate but not multivariable analysis, possibly related to longer wait times.Our findings suggest a relationship between higher BMI, tumor vascular invasion, increased recurrence, and worsened overall survival.
Such studies, when designed, analyzed, and interpreted correctly, can help distinguish genetic from environmental causes that portend increased recurrence of a particular pregnancy complication (eg, recurrence of gestational diabetes) or a perinatal outcome (eg, recurrence of preterm birth or preeclampsia).
Conceptually the association between persistence of symptoms following treatment and subsequent recurrence is particularly straightforward and, indeed, a number of prospective clinical studies have demonstrated significantly increased recurrence rates in patients with such symptoms (e.g., from 25%to7676%) (31,32).
Longer time period between the diagnosis of MPE and onset of treatment could increase recurrence [ 7].
Intriguingly, we observed an association between reduced GPS expression and an increased risk of recurrence in both cohorts (Table 1).
A mathematical algorithm was used to generate a continuous recurrence score (RS), with a higher RS corresponding to an increased risk of recurrence.
Various studies have shown correlations between Ki67 and disease-free and overall survival, with an increased risk of recurrence in tumours with a high Ki67 [ 27- 33].
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