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We found an association between an increased frequency of CD16+ Mo and elevated plasma CCL2, which may be relevant for neuropathogenesis, since high CCL2 levels have been associated with an increased risk of developing HAD [58] and CD16+ Mo produce CCL2 [28].
Another explanation of the correlation between an increased frequency of PD-1+CD4+ T-cells in the peripheral blood and better prognosis is the different distribution of PD-L1 in the peripheral lymph nodes and cancer tissues.
This might explain the association between an increased frequency and severity of clinical symptoms among individuals with dental amalgams and consistently reduced levels of excretion of total mercury in urine (Minoia et al. 2006; Nilsson and Nilsson 1986).
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63 While the G allele frequency is comparable between healthy control, adenoma, and CRC, an increasing frequency is observed when the tumor stage increases, with 14% in the early stages and 21.4%–25.0% in the terminal stage.
‡There is a trend of an increasing frequency of metabolic diseases between 1997 and 2004.
Although the expansion of CD16+ monocytes in RA has been clearly demonstrated in several studies [ 17, 18], it remained unclear until Rossol et al. reported a link between the increased frequency of the CD14brightCD16+ monocyte subpopulation in RA [ 10].
This is relevant because the ECOG 1199 has shown a significant association between black race, increased frequency of obesity and a worse prognosis in ER-positive patients [ 28].
The relationship between the increased frequency of GI manifestations and reduced levels of PUFAs and carnitine was not previously investigated in autistic patients.
In comparing the frequencies of the genotypes between the groups studied, a significantly increased frequency of HP1-1 genotype in healthy individuals versus chagasic patients was observed (18% versus 4%, resp., OR = 0.20, 95% CI: 0.068 0.620, P = 0.002, P c = 0.006).
A strong relationship between a warmer Arctic and increased frequency of severe winter weather is apparent for all stations east of the Rockies, with the strongest association in the eastern third of the US, where we find a statistically significant (p < 0.01) and nearly linear relationship between Arctic height changes throughout the troposphere and AWSSI.
A key point to note about patients with headache attributed to TMD is the association between emotional functioning and increased frequency of headache [19].
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