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The overlap of significant associated markers between all the pathways (carotenoids, tocopherols, chlorophylls and folate) was very limited as expected if we consider that biochemically different precursors are involved.
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To obtain a summarized view, a scatterplot of t-statistics was prepared for each method by correlating t-statistic values of all the pathways between seven pairs of datasets.
The similarities we observe between all simulated pathways suggest that the shape of the free energy well is analogous to the funnel model used to describe protein folding pathways.
Moving from specific crosstalk between two pathways to crosstalk between all pairs of pathways, researchers proposed a global pathway crosstalk network [ 20],[ 21].
"All the pathways are full of trash.
In "Possibilia" there is no such concern, since all the pathways lead to the same outcome.
Here are all the pathways back and forth to be with love, to express love.
Crosstalk was observed between all dysregulated pathways except hsa04514 (Table S5).
Again there were no major changes (p>0.05) in insulin, energy and inflammatory pathways between all the groups (figure 8B in online supplement).
Then, because there can be several paths connecting two discriminating compounds and we want the story to contain all these alternative paths, we impose a constraint of maximality, that is, we search for maximal DAGs, in the sense that alternative pathways between all the nodes should be included, if their addition does not create cycles.
The best way will be to repeat the experiments when measuring both MSN-2-mCherry localization and gene expression in the same cells and to calculate the MI between all steps in the pathway similar to Uda et al. 2013.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com