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Results: In PET scans without Pgp inhibition, Kp,brain values of [11C]VPM were not significantly different between all mouse groups.
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There was no apparent difference in non-adipocyte material in the sections between the mouse groups.
The haplotype conferring resistance is shared between unrelated mouse groups whereas the more closely related Swiss mice and Castle's mice predominantly share the susceptible haplotypes.
While gene ontology (GO) analysis and functional annotation were pointing consistently to differences in metabolic responses between the mouse groups, they did not indicate which individual pathways were affected.
In male mice no difference in carcinoma development was found between the mouse groups.
No differences were detected between the mouse groups in VDAC quantity (VDAC immunoblot Fig. 8b, γ-sarcoglycan control Fig. 8c, and quantified in Fig. 8d).
At the highest concentration used in this study, most of the hair cells were lost and we observed no differences between the mouse groups.
The number of foot processes of the podocytes did not differ between the mouse groups, indicating that the foot process effacement of the podocytes was affected to a similar degree in both mouse groups.
Colon tissue samples were fixed in 10% formalin and undergo histological scoring by H&E staining to detect and compare cellular infiltration, depletion and damage between the different mouse groups.
Both heart-to-body weight and heart weight-to-tibial length ratios were comparable between the two mouse groups.
Significance of the difference in tumor incidence between mouse groups was tested by Chi-Square-test; significance of differences in the levels of blood enzymes, in the levels galectin-1 immunostaining, in the frequency of mitosis and apoptosis, and in the semi-quantitative RT-PCR was tested by t-test.
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