Sentence examples for between activation and repression from inspiring English sources
In case of parafibromin, SHP2-dependent status of the phosphorylation on tyrosine residue of parafibromin is important to shift its transcriptional activity between activation and repression by influencing interaction with β-catenin or SUV39H1.
To distinguish between activation and repression activity of JunD interacting TF partners, the over-representation test was carried out separately for up- and down-regulated target genes (Additional file 1: Table S1).
Vasudevan [28] recently reported that during cell cycle, miRs oscillate between activation and repression; in proliferating cells miRs repress the translation whereas in G1/G0 arrest miRs facilitate translational activation.
In cells with normal amounts of wild-type MLL protein, the overall MLL activity appears to be dependent on the balance between activation and repression.
The molecular mechanisms that control gene expression are still emerging, revealing regulatory circuits that permit a finely tuned transition between activation and repression.
Since Fbxl21 directs degradation of CRY1 and displays strong and specific rhythmic circadian expression within the central pacemaker of the SCN, we suggest that Fbxl21 stands at a crucial crossroads between activation and repression in central clocking (Fig 7).
The switch between transcriptional activation and repression will depend on the formation of these higher-order protein-DNA complexes [39].
Balance between gene activation and repression, as well as mechanisms of maintenance and erasure of expression patterns, require fine gene tuning.
Therefore NF-Y is a fundamental switch at the heart of decision between gene activation and repression in CCAAT regulated genes.
Another report has suggested that mH2A regulates a balance between transcriptional activation and repression through the chromatin remodeling complexes SWI/SNF and ACF [ 13].
It is therefore possible that part of the antagonistic activity of the Cyc8 Tup1 and Swi Snf complexes is acted out at the level of histone acetylation, and that the rapid reversibility of this modification allows for the dynamic switch between gene activation and repression.
