Sentence examples for between activation and detoxification from inspiring English sources

Therefore, imbalances between activation and detoxification processes may result in an increase in bladder cancer risk due to the accumulation of carcinogen metabolites, e.g. from cigarette smoking.

Thus, changes in the balance between activation and detoxification of the metabolism of xenobiotic in the lung cells may have important inflammatory implications.

Therefore, our study has revealed that there is a subtle balance between activation and detoxification of B[ a]P in lung-derived compared with liver-derived cells and that this determines how much DNA damage occurs.

The balance between metabolic activation and detoxification varies among individuals and is likely to affect cancer risk because DNA adducts are central to the carcinogenic process (Tang et al., 2001; Hecht, 1999).

Carcinogens such as NNK require metabolic activation to exert their carcinogenic effects; there are competing detoxification pathways, and the balance between metabolic activation and detoxification differs among individuals and will affect cancer risk.

Potential explanations for the discrepant findings across investigations include inability to identify specific p53 mutational subtypes when using immunohistochemistry as a proxy, differences in metabolic activation and detoxification of PAHs between study populations, and chance findings.

This study served to determine potential correlations between DMBA exposure and oxidative stress in the liver, since metabolic activation and detoxification of DMBA in vivo occur primarily in this organ [ 51, 52].

The present research was designed to investigate the effect of SSRI fluoxetine on antioxidant status and apoptotic signaling in Wistar rat liver, which is a central organ for activation and detoxification of many xenobiotics and reactive oxygen species.

PAHs are metabolized through activation and detoxification pathways.

Metabolic activation and detoxification of sulfur-containing OP insecticides is even more complex.

The authors failed to discuss the issue of chemical activation and detoxification.