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Thus regulation of autophagic activity is integral for T cell to decide between activation and death.
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In this study we examined the dynamics of human DC infection by live pneumococci and we show that there is a fine balance between host cell activation and death following pneumococcal uptake.
Current evidence suggests that a close relation exists between PRL-R, IL-2R, and their ligands, which influences cell growth, activation, and death of immune cells.
Loss of DGKε induces endothelial cell activation and death independently of complement activation.
We found that PERK and IRE1 α pathways cooperate to activate CHOP, and that this appears to be a critical link between inflammasome activation and hepatocyte death in NASH.
The extraordinarily strong association between macrophage activation syndrome and death suggests a high risk of life-threatening malignancies among patients surviving HIV infection [ 16].
Nevertheless, the balance between activation of cell death in cancer cells and protection of healthy tissue remains a concern.
Consecutive induction of cellular activation and cell death is a well known phenomenon in leukocytes and termed activation induced cell death (AICD) [35].
It binds IAPs, allowing caspase activation and cell death.
Moreover, thymocytes from Gadd45β-deficient mice revealed only transient p38 activation, reduced caspase activation and cell death.
Finally, we characterized the interplay between HICC activation and STS-induced cell death and apoptosis.
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