HDR was delivered using an afterloading device, with the prescribed dose delivered using 5 6 Gy per fractions twice daily with at least 6 hours between fractions to a total dose of 30 Gy.
A total of 184 consecutive patients (median age 65 years, male : female=2 : 1) with clinical T3Nx rectal adenocarcinoma received preoperative pelvic radiation therapy with single fractions of 2.5 Gy twice daily (interval 6 h between fractions) to a total dose of 25 Gy within 1 week.
The majority of patients (78%, range=57%-95%) received a total dose between 150 and 200 units.
Twelve patients with histories of histologically-confirmed neoplasia received a total dose between 1.0 and 4.4 mCi of 131I-labeled goat IgG prepared against human alpha-fetoprotein.
Typically, rATG is now given at a total dose ranging between 4.5 and 7.5 mg/kg within myeloablative conditioning regimens [ 224, 226, 230].
In 2007, the reimbursement per stay in hospital for a total dose of L-AmB of between 2,150 and 3,150 mg is €4,744.70, while that for a total dose of caspofungin of between 600 and 700 mg is €5,150.90.
It is well known that there is a correlation between the total dose of nucleated cells transplanted per kilogram of body weight of the recipient and outcome.
This was a ratio between the total dose of MTX administered (mgm−2) and the treatment duration expressed in days divided by 7. Treatment duration was calculated from the first day of the first course to the 22nd or 29th day of the last course (respectively for regimens administered every 3 or 4 weeks) (Hryniuk and Goodyear, 1990).
Important key differences between RIT and EBRT include a lower total dose of radiation, a much lower dose rate of radiation delivery over prolonged periods of time, more akin to brachytherapy, and, finally, an exponentially decreasing dose rate.
Absorption of poorly soluble, slowly absorbed molecules can obviously result in a complete lack of correlation between the total dose deposited in the lung and the resulting systemic exposure.
