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A common problem in interpreting the finding of an association between a polymorphism and a clinical outcome is demonstrated in the study conducted by Schluter and colleagues [ 43].
DNA methylation, for example, mediates the relation between a polymorphism and developmental outcomes by changing the expression of the gene (Van IJzendoorn et al. 2011).
The correlation between a polymorphism and relapse status was assessed using the relative risk ratio and a 95% confidence interval (CI).
A χ-test with Yates' correction was used to give a conservative test for the significance of any association between a polymorphism and colorectal cancer.
Although a relationship between a polymorphism and in vitro responses was recently shown for an IL23R variant (Di Meglio et al., 2011), for most gene associations, functional effects of SNPs remain to be determined.
According to the Q-test P-value, the association between a polymorphism and cancer risk was investigating using either the fixed- or the random-effects models, according to the method of DerSimonian and Laird.
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In future, correlation between Aurora-A polymorphism and risk of development of primary lung cancer should be investigated.
Searching several databases yielded 24 independent studies that reported on the associations between TNF-A polymorphisms and gastric cancer risk.
In the present study a single panmictic population, a synthetic variety, allowed us to detect a strong association between a SNP polymorphism and a trait.
Association between a gene polymorphism and a phenotype in a genetic-epidemiological study may, in isolation, convey little information about the causative role of the polymorphism.
Only a few studies observed a relationship between a GST polymorphism and Hg concentration.
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